search for


Research status of the development of genetically modified papaya (Carica papaya L.) and its biosafety assessment
J Plant Biotechnol 2018;45:171-182
Published online September 30, 2018
© 2018 The Korean Society for Plant Biotechnology.

Ho Bang Kim, Yi Lee, Chang-Gi Kim

Life Sciences Research Institute, Biomedic Co., Ltd., Bucheon 14548, Korea
Department of Industrial Plant Science and Technology,
Chungbuk National University, Cheongju 28644, Korea
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea
Correspondence to: e-mail:
Received April 10, 2018; Revised May 21, 2018; Accepted June 1, 2018.
cc This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Papaya (Carica papaya L.) is one of the crops widely planted in tropical and subtropical areas. The papaya fruit has low calories and are plentiful in vitamins A and C and in minerals. A major problem in papaya production is a plant disease caused by the papaya ringspot virus (PRSV). The first PRSV-resistant GM papaya expressing a PRSV coat protein gene was developed by USA scientists in 1992. The first commercial GM papaya cultivars derived from the event was approved by the US government in 1997. Development of transgenic papayas has been focused on vaccine production and limited agricultural traits, including insect and pathogen resistance, long shelf life, and aluminum and herbicide tolerance. Approximately 17 countries, including the USA and China, produced transgenic papayas and/or commercialized them, which provoked studies on biosafety assessment and development of GM-detection technologies. For the biosafety assessment of potential effects on human health, effects of long-term feeding to model animals have been studied in terms of toxicity and allergenicity. Studies on environmental safety assessment include influence on soilmicrobial biodiversity and transfer to soil bacteria of GM selection markers. Many countries, such as Korea, the European Union, and Japan, that have strict regulations for GM crops have serious concerns about unintended introduction of GM cultivars and food commodities using unauthorized GM crops. Transgene- and/or GM event-specific molecular markers and technologies for genomics-based detection of unauthorized GM papaya have been developed and have resulted in the robust detection of GM papayas.
Keywords : Caricapapaya, GM-detection technology, papaya, transformation, transgenic papaya, biosafety assessment

September 2018, 45 (3)
Full Text(PDF) Free

Social Network Service

Cited By Articles
  • CrossRef (0)
  • CrossMark
  • Crossref TDM