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Ginsenoside composition of Panax ginseng flower extracts obtained using different high hydrostatic pressure extraction conditions
J Plant Biotechnol 2019;46:56-60
Published online March 31, 2019
© 2019 The Korean Society for Plant Biotechnology.

Hyun Soo Kim, Gyu Ri Kim, Donghyun Kim, Cheng-Yi Zhang, Eun-Soo Lee, Nok Hyun Park, Junseong Park, Chang Seok Lee and Moon Sam Shin

Amorepacific R&D Center, Yongin 17074, Korea
Department of Beauty and Cosmetic Science, Eulji University, Seongnam 13135, Korea
Department of Engineering Chemistry, Chungbuk National University, Cheongju 54896, Korea
Correspondence to: e-mail:
These authors contributed equally to this work.
Received February 1, 2019; Revised February 26, 2019; Accepted February 26, 2019.
cc This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ginsenosides are active constituents of ginseng (Panax ginseng) that have possible anti-aging, physiological and pharmacological activities, such as anti-cancer and anti-inflammatory effects. Although the ginseng root is generally used more often than the aerial parts for medicinal purposes, the flowers also contain numerous ginsenosides, including Rb2, Rc, Rd, Re and Rg1. Therefore, an extract from the flowers of the P. ginseng could have the pharmacological efficacy of bioactive compounds including ginsenosides. The high hydrostatic pressure extraction (HHPE) is a method that is used for the efficient extraction of bioactive compounds from plant materials. In this study, we compared the yield of ginsenosides from ginseng flowers under different conditions of extraction pressure and time of HHPE. The results indicate that the total yield of the ginsenosides improved as the pressure increased from 0.1 to 80 MPa and treatment duration increased to 24 hours. In addition, the ginsenoside extracts from HHPE at 80 MPa, which possessed a higher total ginsenoside concentration, decreased the viability of the primary human epidermal keratinocytes (HEKs) significantly than the ginsenoside extracts from HHPE at 0.1 MPa. Collectively, we found that the method of HHPE that was performed for 24 hours at 80 MPa showed the highest yield of ginsenosides from the flowers of P. ginseng. In addition, our study provides a foundation for the efficient extraction of ginsenosides, which had a potent bioactivity, from flowers of P. ginseng through HHPE.
Keywords : Ginsenoside, Panax ginseng, High hydrostatic Pressure extraction (HHPE), Cell viability

March 2019, 46 (1)
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