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Current status of comparative compositional analysis for GM crop biosafety assessment
J Plant Biotechnol 2020;47:261-272
Published online December 31, 2020
© 2020 The Korean Society for Plant Biotechnology.

Eun-Ha Kim・Seon-Woo Oh ・Sang-Gu Lee ・Sung-Kon Lee ・Tae-Hun Ryu

Biosafety Division, National Institute of Agricultural Sciences, 370 Nongsaengmyeong-ro, Jeonju, Jollabuk-do 54875, South Korea
R&D Coordination Division, Rural Development Administration, 300 Nongsaengmyeong-ro, Jeonju, Jollabuk-do 54875, South Korea
Correspondence to: e-mail:
Received November 4, 2020; Revised December 3, 2020; Accepted December 3, 2020.
cc This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Approvals for cultivation and import of genetically modified (GM) crops have dramatically increased around the world. Comparative compositional studies are an important aspect of safety assessments of products from GM crops and are based on substantial equivalence. Compositional analyses focus on determining similarities and differences between the compositions of the GM crops and their conventional counterparts, and thereby assessing the compositional equivalence of GM crops and their conventional comparators. The analytes, such as major constituents, key nutrients, and antinutrients, are generally determined on a crop-specific basis according to the OECD consensus document. The use of standard methods throughout the processes, such as selection of comparators, field trials, analytical methods, and statistical data analysis, is crucial. In this study, we showed the general framework of compositional studies. Literature for compositional studies of GM crops conducted abroad and in Korea was reviewed to obtain information about analytes, conventional counterparts, cultivation year, location, and statistical methods. The studies conducted abroad assessed for commercial release of GM crops such as soybean, maize, and cotton, while domestic studies were mainly performed for research in rice. In addition, we suggested a guidance for conventional comparators and field trials applicable to the domestic situation.
Keywords : GMO, Biosafety, Substantial equivalence, Nutrient composition

December 2020, 47 (4)
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